- Prognostic Impact of Fusobacterium nucleatum Depends on Combined Tumor Location and Microsatellite Instability Status in Stage II/III Colorectal Cancers Treated with Adjuvant Chemotherapy
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Hyeon Jeong Oh, Jung Ho Kim, Jeong Mo Bae, Hyun Jung Kim, Nam-Yun Cho, Gyeong Hoon Kang
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J Pathol Transl Med. 2019;53(1):40-49. Published online December 26, 2018
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DOI: https://doi.org/10.4132/jptm.2018.11.29
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 Abstract
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- Background
This study aimed to investigate the prognostic impact of intratumoral Fusobacterium nucleatum in colorectal cancer (CRC) treated with adjuvant chemotherapy.
Methods
F. nucleatumDNA was quantitatively measured in a total of 593 CRC tissues retrospectively collectedfrom surgically resected specimens of stage III or high-risk stage II CRC patients who had receivedcurative surgery and subsequent oxaliplatin-based adjuvant chemotherapy (either FOLFOXor CAPOX). Each case was classified into one of the three categories: F. nucleatum–high, –low, or –negative.
Results
No significant differences in survival were observed between the F.nucleatum–high and –low/negative groups in the 593 CRCs (p = .671). Subgroup analyses accordingto tumor location demonstrated that disease-free survival was significantly better in F.nucleatum–high than in –low/negative patients with non-sigmoid colon cancer (including cecal,ascending, transverse, and descending colon cancers; n = 219; log-rank p = .026). In multivariateanalysis, F. nucleatum was determined to be an independent prognostic factor in non-sigmoidcolon cancers (hazard ratio, 0.42; 95% confidence interval, 0.18 to 0.97; p = .043). Furthermore,the favorable prognostic effect of F. nucleatum–high was observed only in a non-microsatellite instability-high (non-MSI-high) subset of non-sigmoid colon cancers (log-rank p = 0.014), but not ina MSI-high subset (log-rank p = 0.844), suggesting that the combined status of tumor locationand MSI may be a critical factor for different prognostic impacts of F. nucleatum in CRCs treatedwith adjuvant chemotherapy.
Conclusions
Intratumoral F. nucleatum load is a potential prognosticfactor in a non-MSI-high/non-sigmoid/non-rectal cancer subset of stage II/III CRCs treatedwith oxaliplatin-based adjuvant chemotherapy.
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Citations
Citations to this article as recorded by  - Composition of the colon microbiota in the individuals with inflammatory bowel disease and colon cancer
Ceren Acar, Sibel Kucukyildirim Celik, H. Ozgur Ozdemirel, Beril Erdem Tuncdemir, Saadet Alan, Hatice Mergen
Folia Microbiologica.2024; 69(2): 333. CrossRef - Intratumoral microorganisms in tumors of the digestive system
Mengjuan Xuan, Xinyu Gu, Yingru Liu, Li Yang, Yi Li, Di Huang, Juan Li, Chen Xue
Cell Communication and Signaling.2024;[Epub] CrossRef - Prognostic impact of oral microbiome on survival of malignancies: a systematic review and meta-analysis
Shuluan Li, Tianyu Wang, Ya Ren, Zhou Liu, Jidong Gao, Zhi Guo
Systematic Reviews.2024;[Epub] CrossRef - Exploring the Potential of Humoral Immune Response to Commensal Bifidobacterium as a Biomarker for Human Health, including Both Malignant and Non-Malignant Diseases: A Perspective on Detection Strategies and Future Directions
Kyogo Itoh, Satoko Matsueda
Biomedicines.2024; 12(4): 803. CrossRef - Unveiling intratumoral microbiota: An emerging force for colorectal cancer diagnosis and therapy
Jinjing Zhang, Penghui Wang, Jiafeng Wang, Xiaojie Wei, Mengchuan Wang
Pharmacological Research.2024; 203: 107185. CrossRef - Intratumoral microbiota: roles in cancer initiation, development and therapeutic efficacy
Li Yang, Aitian Li, Ying Wang, Yi Zhang
Signal Transduction and Targeted Therapy.2023;[Epub] CrossRef - Increased Fusobacterium tumoural abundance affects immunogenicity in mucinous colorectal cancer and may be associated with improved clinical outcome
William P. Duggan, Manuela Salvucci, Batuhan Kisakol, Andreas U. Lindner, Ian S. Reynolds, Heiko Dussmann, Joanna Fay, Tony O’Grady, Daniel B. Longley, Fiona Ginty, Elizabeth Mc Donough, Daniel J. Slade, John P. Burke, Jochen H. M. Prehn
Journal of Molecular Medicine.2023; 101(7): 829. CrossRef -
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Koki Takeda, Minoru Koi, Yoshiki Okita, Sija Sajibu, Temitope O. Keku, John M. Carethers
Cancer Research Communications.2023; 3(9): 1940. CrossRef - La asociación entre Fusobacterium nucleatum y el cáncer colorrectal: una revisión sistemática y metaanálisis
Paola Villar-Ortega, Manuela Expósito-Ruiz, Miguel Gutiérrez-Soto, Miguel Ruiz-Cabello Jiménez, José María Navarro-Marí, José Gutiérrez-Fernández
Enfermedades Infecciosas y Microbiología Clínica.2022; 40(5): 224. CrossRef - The association between Fusobacterium nucleatum and cancer colorectal: A systematic review and meta-analysis
Paola Villar-Ortega, Manuela Expósito-Ruiz, Miguel Gutiérrez-Soto, Miguel Ruiz-Cabello Jiménez, José María Navarro-Marí, José Gutiérrez-Fernández
Enfermedades infecciosas y microbiologia clinica (English ed.).2022; 40(5): 224. CrossRef - Suppression of Berberine and Probiotics (in vitro and in vivo) on the Growth of Colon Cancer With Modulation of Gut Microbiota and Butyrate Production
Chao Huang, Ying Sun, Sheng-rong Liao, Zhao-xin Chen, Han-feng Lin, Wei-zeng Shen
Frontiers in Microbiology.2022;[Epub] CrossRef - Prognostic and clinicopathological significance of Fusobacterium nucleatum in colorectal cancer: a systemic review and meta-analysis
Younghoon Kim, Nam Yun Cho, Gyeong Hoon Kang
Journal of Pathology and Translational Medicine.2022; 56(3): 144. CrossRef - Iron accelerates Fusobacterium nucleatum–induced CCL8 expression in macrophages and is associated with colorectal cancer progression
Taishi Yamane, Yohei Kanamori, Hiroshi Sawayama, Hiromu Yano, Akihiro Nita, Yudai Ohta, Hironori Hinokuma, Ayato Maeda, Akiko Iwai, Takashi Matsumoto, Mayuko Shimoda, Mayumi Niimura, Shingo Usuki, Noriko Yasuda-Yoshihara, Masato Niwa, Yoshifumi Baba, Taka
JCI Insight.2022;[Epub] CrossRef - Clinicopathological differences of high Fusobacterium nucleatum levels in colorectal cancer: A review and meta-analysis
Yi Wang, Yuting Wen, Jiayin Wang, Xin Lai, Ying Xu, Xuanping Zhang, Xiaoyan Zhu, Chenglin Ruan, Yao Huang
Frontiers in Microbiology.2022;[Epub] CrossRef - Clinical Significance of Fusobacterium nucleatum and Microsatellite Instability in Evaluating Colorectal Cancer Prognosis
Yanxuan Xie, Xiaoyang Jiao, Mi Zeng, Zhiqiang Fan, Xin Li, Yumeng Yuan, Qiaoxin Zhang, Yong Xia
Cancer Management and Research.2022; Volume 14: 3021. CrossRef - Influence of the Microbiome Metagenomics and Epigenomics on Gastric Cancer
Precious Mathebela, Botle Precious Damane, Thanyani Victor Mulaudzi, Zilungile Lynette Mkhize-Khwitshana, Guy Roger Gaudji, Zodwa Dlamini
International Journal of Molecular Sciences.2022; 23(22): 13750. CrossRef - Circulating IgA Antibodies Against Fusobacterium nucleatum Amyloid Adhesin FadA are a Potential Biomarker for Colorectal Neoplasia
Jung Eun Baik, Li Li, Manish A. Shah, Daniel E. Freedberg, Zhezhen Jin, Timothy C. Wang, Yiping W. Han
Cancer Research Communications.2022; 2(11): 1497. CrossRef - Differential immune microenvironmental features of microsatellite-unstable colorectal cancers according to Fusobacterium nucleatum status
Ji Ae Lee, Seung-Yeon Yoo, Hyeon Jeong Oh, Seorin Jeong, Nam-Yun Cho, Gyeong Hoon Kang, Jung Ho Kim
Cancer Immunology, Immunotherapy.2021; 70(1): 47. CrossRef - Fusobacterium nucleatum and Clinicopathologic Features of Colorectal Cancer: Results From the ColoCare Study
Yannick Eisele, Patrick M. Mallea, Biljana Gigic, W. Zac Stephens, Christy A. Warby, Kate Buhrke, Tengda Lin, Juergen Boehm, Petra Schrotz-King, Sheetal Hardikar, Lyen C. Huang, T. Bartley Pickron, Courtney L. Scaife, Richard Viskochil, Torsten Koelsch, A
Clinical Colorectal Cancer.2021; 20(3): e165. CrossRef - Role of gut microbiota in epigenetic regulation of colorectal Cancer
Yinghui Zhao, Chuanxin Wang, Ajay Goel
Biochimica et Biophysica Acta (BBA) - Reviews on Cancer.2021; 1875(1): 188490. CrossRef - Fusobacterium nucleatum: caution with interpreting historical patient sample cohort
Kate L. F. Johnstone, Sinead Toomey, Stephen Madden, Brian D. P. O’Neill, Bryan T Hennessy
Journal of Pathology and Translational Medicine.2021; 55(6): 415. CrossRef -
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Yung-Yu Hsieh, Shui-Yi Tung, Hung-Yu Pan, Te-Sheng Chang, Kuo-Liang Wei, Wei-Ming Chen, Yi-Fang Deng, Chung-Kuang Lu, Yu-Hsuan Lai, Cheng-Shyong Wu, Chin Li
World Journal of Gastroenterology.2021; 27(42): 7311. CrossRef - Analysis of changes in microbiome compositions related to the prognosis of colorectal cancer patients based on tissue-derived 16S rRNA sequences
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Journal of Translational Medicine.2021;[Epub] CrossRef - Gastrointestinal tumors and infectious agents: A wide field to explore
Miriam López-Gómez, Belén García de Santiago, Pedro-David Delgado-López, Eduardo Malmierca, Jesús González-Olmedo, César Gómez-Raposo, Carmen Sandoval, Pilar Ruiz-Seco, Nora Escribano, Jorge Francisco Gómez-Cerezo, Enrique Casado
World Journal of Meta-Analysis.2021; 9(6): 505. CrossRef - Gut Microbiota Profiles in Early- and Late-Onset Colorectal Cancer: A Potential Diagnostic Biomarker in the Future
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Digestion.2021; 102(6): 823. CrossRef - The effect of periodontal bacteria infection on incidence and prognosis of cancer
Li Xiao, Qianyu Zhang, Yanshuang Peng, Daqing Wang, Ying Liu
Medicine.2020; 99(15): e19698. CrossRef - The impact of the gut microbiota on prognosis after surgery for colorectal cancer – a systematic review and meta‐analysis
Emilie Palmgren Colov, Thea Helene Degett, Hans Raskov, Ismail Gögenur
APMIS.2020; 128(2): 162. CrossRef - Can the microbiota predict response to systemic cancer therapy, surgical outcomes, and survival? The answer is in the gut
Khalid El Bairi, Rachid Jabi, Dario Trapani, Hanae Boutallaka, Bouchra Ouled Amar Bencheikh, Mohammed Bouziane, Mariam Amrani, Said Afqir, Adil Maleb
Expert Review of Clinical Pharmacology.2020; 13(4): 403. CrossRef - Predictive values of colon microbiota in the treatment response to colorectal cancer
Jorge Galan-Ros, Verónica Ramos-Arenas, Pablo Conesa-Zamora
Pharmacogenomics.2020; 21(14): 1045. CrossRef - The gut microbiome and potential implications for early-onset colorectal cancer
Reetu Mukherji, Benjamin A Weinberg
Colorectal Cancer.2020;[Epub] CrossRef -
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Christian Gethings-Behncke, Helen G. Coleman, Haydee W.T. Jordao, Daniel B. Longley, Nyree Crawford, Liam J. Murray, Andrew T. Kunzmann
Cancer Epidemiology, Biomarkers & Prevention.2020; 29(3): 539. CrossRef - CpG Island Methylation in Sessile Serrated Adenoma/Polyp of the Colorectum: Implications for Differential Diagnosis of Molecularly High-Risk Lesions among Non-dysplastic Sessile Serrated Adenomas/Polyps
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Journal of Pathology and Translational Medicine.2019; 53(4): 225. CrossRef - Fusobacterium nucleatum tumor DNA levels are associated with survival in colorectal cancer patients
Andrew T. Kunzmann, Marcela Alcântara Proença, Haydee WT Jordao, Katerina Jiraskova, Michaela Schneiderova, Miroslav Levy, Václav Liska, Tomas Buchler, Ludmila Vodickova, Veronika Vymetalkova, Ana Elizabete Silva, Pavel Vodicka, David J. Hughes
European Journal of Clinical Microbiology & Infectious Diseases.2019; 38(10): 1891. CrossRef - Gut Microbiome: A Promising Biomarker for Immunotherapy in Colorectal Cancer
Sally Temraz, Farah Nassar, Rihab Nasr, Maya Charafeddine, Deborah Mukherji, Ali Shamseddine
International Journal of Molecular Sciences.2019; 20(17): 4155. CrossRef - The Four Horsemen in Colon Cancer
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Journal of Oncology.2019; 2019: 1. CrossRef - The role of Fusobacterium nucleatum in colorectal cancer: from carcinogenesis to clinical management
Chun‐Hui Sun, Bin‐Bin Li, Bo Wang, Jing Zhao, Xiao‐Ying Zhang, Ting‐Ting Li, Wen‐Bing Li, Di Tang, Miao‐Juan Qiu, Xin‐Cheng Wang, Cheng‐Ming Zhu, Zhi‐Rong Qian
Chronic Diseases and Translational Medicine.2019; 5(3): 178. CrossRef
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